| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314825 | Journal of Fluorine Chemistry | 2007 | 8 Pages |
Abstract
When associated with an alkaline halide, such as cesium fluoride or cesium chloride, and Cu(I) species, methyl trifluoroacetate (MTFA) constitutes a valuable trifluoromethylating agent for substituting aromatic (or heteroaromatic) iodides and bromides. The reaction can be carried out in DMF at 180 °C or, better, in sulfolane which allows he reaction to proceed at a lower temperature (from 140 °C).
Graphical abstractAssociated with cesium fluoride or cesium chloride and CuI, methyl trifluoroacetate (MTFA) constitutes a trifluoromethylating agent for substituting aromatic (or heteroaromatic) iodides and bromides.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Bernard R. Langlois, Nicolas Roques,