Fluorinated nucleosides: Synthesis and biological implication

A number of important pharmaceuticals have been discovered and developed based on fluorinated analogs of biologically active nucleosides. The introduction of fluorine into a nucleoside structure at an appropriate position has modulated and/or improved the pharmacological properties of a molecule. The present review deals with the synthetic methodology, structural and biological implication of carbohydrate-modified fluoronucleosides.

Graphical abstractA number of important pharmaceuticals have been discovered based on fluorinated analogs of biologically active nucleosides. The introduction of fluorine at an appropriate position has modulated and/or improved the pharmacological properties of nucleosides. The present review deals with the synthetic methodology, structural and biological implication of carbohydrate-modified fluoronucleosides.Figure optionsDownload full-size imageDownload as PowerPoint slide