Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1314866 | Journal of Fluorine Chemistry | 2010 | 5 Pages |
Abstract
A whole series of 3-(mono-, di-, trifluoro)methyl-substituted N-benzylpyrrolidinones 5a–c was synthesized by deoxyfluorination of corresponding 3-functionalized N-benzylpyrrolidinones. New β-trifluoromethyl containing GABA 4a was obtained in two alternative ways: by successive hydrolysis and hydrogenolysis of 3-trifluoromethyl N-benzylpyrrolidinone 5a and from trifluoroacetone as starting compound.
Graphical abstractA series of 3-(mono-, di-, trifluoro)methyl containing N-benzylpyrrolidinones 5a–c was synthesized by deoxyfluorination reactions. New β-trifluoromethyl containing GABA 4a was obtained by two different ways.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Igor I. Gerus, Roman V. Mironets, Elena N. Shaitanova, Valery P. Kukhar,