| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314888 | Journal of Fluorine Chemistry | 2011 | 5 Pages |
Abstract
We propose a decagram synthesis of commercially unavailable fluorocitric acid. The synthesis begins with benzyl fluoroacetate, which is converted to dibenzyl 2-fluoro-3-oxosuccinate, followed by condensation with malonic acid or its monobenzyl ester and subsequent hydrogenolysis.
Graphical abstractBulk synthesis of commercially unavailable fluorocitric acid has been proposed, starting from dibenzyl 2-fluoro-3-oxosuccinate.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Synthesis was accomplished starting from dibenzyl 2-fluoro-3-oxosuccinate followed by condensation with malonic acid or its monobenzyl ester. ► Hydrogenolysis instead of hydrolysis gave quantitative yields of d,l-fluorocitric acid.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Ruben Vardanyan, Vlad K. Kumirov, Victor J. Hruby,