| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314908 | Journal of Fluorine Chemistry | 2012 | 5 Pages |
Abstract
Herein, we report a new and convenient method for the synthesis of β-fluoro-α-aminophosphonates starting from naturally occurring l-amino acids. A key step in the synthetic protocol involves nucleophilic fluorination of N,N-dibenzylated-β-amino alcohols with diethylaminosulfur trifluoride (DAST).
Graphical abstract.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► An easy access to β-fluoro-α-aminophosphonates. ► Formation of an aziridinium ion as the key step of the synthesis. ► DAST mediated fluorination.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Marcin Kaźmierczak, Henryk Koroniak,