Fluoroalkylation of pent-4-en-1-ols initiated by sodium dithionite to synthesize fluorine-containing tetrahydrofuran derivatives

Fluoroalkylation of pent-4-en-1-ols with RCF2I initiated by Na2S2O4 was carried out at 5–10 °C in aqueous acetonitrile affording corresponding adducts, which were converted to fluoroalkyl tetrahydrofurans by heating in DMF or acetonitrile, providing a convenient method for the synthesis of fluorine-containing tetrahydrofuran derivatives.

Graphical abstractFluoroalky tetrahydrofuran derivatives were obtained by reaction of pent-4-en-1-ols with RCF2I initiated by Na2S2O4 followed by heating in DMF or acetonitrile.Figure optionsDownload full-size imageDownload as PowerPoint slide