| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1314961 | Journal of Fluorine Chemistry | 2011 | 7 Pages |
A catalyst free cycloaddition reaction of 3-oxo-1,2-pyrazolidinium ylides with β-trifluoroacetyl vinyl ethyl ether is reported, which proceeded smoothly at ambient temperature and afford the bicyclic pyrazolidinone products in good yield. This is the first report of synthesis of 6-trifluoroacetyl substituted bicyclic pyrazolidinones that are potentially anti-microbial and herbicidal.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A catalyst free cycloaddition reaction of 3-oxo-1,2-pyrazolidinium ylides with β-trifluoroacetyl vinyl ethyl ether is reported. ► The reaction proceeded smoothly at ambient temperature and afford the bicyclic pyrazolidinone products in good yield. ► The reaction proceeded via a 1,3-cycloaddition-elimination process. ► This is the first report of synthesis of 6-trifluoroacetyl substituted bicyclic pyrazolidinones.
