l-Proline catalyzed condensation–cyclization tandem process: Facile and effective synthesis of 3-polyfluoroalkanesulfonyl coumarin

A l-proline catalyzed condensation–cyclization tandem process is reported, which affords the potentially pharmaceutic coumarin derivatives. The mild conditions, simplicity of the purification process and satisfactory yields makes the method a facile and effective way toward the 3-polyfluoroalkanesulfonyl coumarins.

Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A l-proline catalyzed condensation–cyclization tandem process is reported. ► The reaction gave the potentially pharmaceutic coumarin derivatives in good yields. ► The mild condition, simplicity of the purification process and satisfactory yields makes the method a facile and effective way toward the 3-polyfluoroalkanesulfonyl coumarins. ► And a possible reaction pathway was proposed.