Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1314985 | Journal of Fluorine Chemistry | 2012 | 6 Pages |
A variety of substituted β-(trifluoromethyl)pyrroles were easily synthesized in good yields by a one-pot, three-component Grob cyclization of 1,1,1-trifluoro-3-nitrobut-2-ene with 1,3-dicarbonyls (ethyl acetoacetate, acetylacetone, benzoylacetone) and ammonia or primary aliphatic amines.
Graphical abstractA variety of substituted β-(trifluoromethyl)pyrroles were easily synthesized in good yields by a one-pot, three-component Grob cyclization of 1,1,1-trifluoro-3-nitrobut-2-ene with 1,3-dicarbonylic compounds (ethyl acetoacetate, acetylacetone, and benzoylacetone) and ammonia or primary aliphatic amines.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► 1,1,1-Trifluoro-3-nitrobut-2-ene, 1,3-dicarbonylic compounds, and ammonia or primary amines were used. ► Three-component synthesis of highly substituted β-(trifluoromethyl)pyrroles was described. ► The reaction slightly depends on the substituent of the active methylene compound.