Synthesis and fungicidal activity of new fluorine-containing mandelic acid amide compounds

A series of novel fluorine-containing mandelic acid amide compounds were designed and synthesized by a facile method, and their structures were characterized by 1H nuclear magnetic resonance (NMR) and high-resolution mass spectrometry. The preliminary in vivo bioassays indicated that some of the title compounds showed excellent fungicidal activities in vivo against Pseudoperonospora cubensis at the dosage of 25 mg L−1, which were comparable with the control (Mandipropamid).

Graphical abstractA series of novel fluorine containing mandelic acid amide compounds were designed and synthesized by a facile method, and their structures were characterized by 1H nuclear magnetic resonance (NMR) and high-resolution mass spectrometry. The preliminary fungicidal activities bioassays indicated that some of the title compounds showed excellent fungicidal activities in vivo against Pseudoperonospora cubensis at the dosage of 25 mg L−1, which are comparable with the control (Mandipropamid).Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Novel fluorine containing mandelic acid amide compounds were synthesized. ► The title compounds showed excellent fungicidal activities. ► The fungicidal activity are closely related to degree of unsaturation of R2.