| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1315101 | Journal of Fluorine Chemistry | 2007 | 5 Pages |
Abstract
A novel synthetic route to 3-deoxy-3,3-difluoro-d-ribohexose 1 has been developed. Dihydroxidation of gem-difluorohomoallyl alcohol followed by several steps of protection and deprotection gave key intermediate 9. Oxidation of 1,5-diol 9 with 2 equiv. trichloroisocyanuric acid and catalytic TEMPO gave lactone 10. Reduction of 10 with DIBAL-H followed by deprotections afforded the target molecule 1.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Xiu-Hua Xu, Zheng-Wei You, Xingang Zhang, Feng-Ling Qing,