| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1315228 | Journal of Fluorine Chemistry | 2007 | 6 Pages |
Abstract
β-Lactams bearing a Ph2CF substituent at the C(4)-atom were synthesized from N-alkyl-2-fluoro-3,3-diphenylaziridines. The transformation was realized using SbF3-mediated isomerization of the monofluoroaziridines to fluorinated aldimines, followed by Staudinger reaction with ketenes. It was shown that this reaction sequence can be performed as a one-pot procedure.
Graphical abstractβ-Lactams bearing a Ph2CF substituent at the C(4)-atom were synthesized from N-alkyl-2-fluoro-3,3-diphenylaziridines. Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Alexander S. Konev, Mikhail S. Novikov, Alexander F. Khlebnikov, Kourosch Abbaspour Tehrani,