| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1315306 | Journal of Fluorine Chemistry | 2006 | 9 Pages |
Abstract
4-Bromodifluoromethyl β-lactams 2 are prepared from the commercial available BrCF2CF2Br in overall five-step reaction procedure. Under the radical reaction conditions (Bu3SnH/AIBN), compound 2 reacted with alkenes affording to the corresponding addition product difluoromethylene β-lactams 7. In the absence of alkenes, it can be converted into the corresponding difluoromethyl β-lactam 6 in almost quantitative yield. Furthermore, allylic stannic reagent Bu3SnCH2CHCH2 reacted with 2 under the same reaction conditions gave the allylic addition product 8.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Hui Wang, Shifa Zhu, Chunhui Xing, Wan Pang, Qinying Deng, Shizheng Zhu,