Perfluoroalkylated-pyridine catalyzed Aldol condensations of aldehydes and ketones in a fluorous biphasic system without fluorous solvent

Aldol condensation of different ketones with various aromatic aldehydes proceeds efficiently in the presence of catalytic amount of perfluoroalkylated-pyridine in a fluorous biphasic system without fluorous solvent, which has prompted various concerns involving cost, solvent leaching, and environmental persistence. The catalyst can be recovered by simple cooling and precipitation and used again.

Graphical abstractAldol condensation proceeds efficiently in the presence of catalytic amount of perfluoroalkylated-pyridine under homogeneous conditions in n-octane at 80 °C. The catalyst can be recovered by simple liquid/solid phase separation at 0 °C in the absence of fluorous solvent.Figure optionsDownload full-size imageDownload as PowerPoint slide