| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1315438 | Journal of Fluorine Chemistry | 2008 | 4 Pages |
Abstract
Phase-vanishing (PV) method using perfluorohexanes as a screen phase was applied to cyclopropanation reactions with CH2I2/Et2Zn and CH2I2/Et3Al. When Et3Al was used as a carbenoid generator, the reaction proceeded smoothly and desired cyclopropane derivatives were obtained in high yield. The PV cyclopropanation took 2 or 3 days to complete, however, reduction of reaction time by a factor of 2–3 was also achieved by vigorous stirring after the bottom CH2I2 layer disappeared.
Graphical abstractCyclopropanation reactions with the Maruoka–Yamamoto reagent (Et3Al/CH2I2) were carried out successfully using fluorous media as a phase screen. Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Hiroshi Matsubara, Masaaki Tsukida, Shinji Yasuda, Ilhyong Ryu,