Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1315482 | Journal of Fluorine Chemistry | 2008 | 4 Pages |
Abstract
A facile and highly efficient nucleophilic (phenylthio)difluoromethylation of alkyl halides has been achieved via fluoride ion-mediated substitution reaction using [difluoro(phenylthio)methyl]trimethylsilane (Me3SiCF2SPh). The reaction proceeds well with primary alkyl bromides (or alkyl iodides) in DME solvent when CsF/15-crown-5 was used as the fluoride source/additive. The PhSCF2-containing products can be readily transformed into CF2H-containing compounds via a free-radical desulfurization method.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Ya Li, Jinbo Hu,