Article ID Journal Published Year Pages File Type
1315482 Journal of Fluorine Chemistry 2008 4 Pages PDF
Abstract

A facile and highly efficient nucleophilic (phenylthio)difluoromethylation of alkyl halides has been achieved via fluoride ion-mediated substitution reaction using [difluoro(phenylthio)methyl]trimethylsilane (Me3SiCF2SPh). The reaction proceeds well with primary alkyl bromides (or alkyl iodides) in DME solvent when CsF/15-crown-5 was used as the fluoride source/additive. The PhSCF2-containing products can be readily transformed into CF2H-containing compounds via a free-radical desulfurization method.

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Related Topics
Physical Sciences and Engineering Chemistry Inorganic Chemistry
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