Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1315610 | Journal of Fluorine Chemistry | 2007 | 5 Pages |
Abstract
Palladium catalysed Suzuki cross-coupling reactions between 2,4,6-tribromo-3,5-difluoropyridine and a short series of aromatic boronic acid derivatives gave 4-bromo-3,5-difluoro-2,6-diphenylpyridine derivatives arising from displacement of bromine atoms attached to positions ortho to ring nitrogen or the corresponding triaryl systems depending on the reaction conditions. Consequently, the use of polybromofluoropyridine scaffolds for the synthesis of polyfunctional heteroaromatic derivatives is expanded further.
Graphical abstractPalladium catalysed Suzuki cross-coupling reactions between 2,4,6-tribromo-3,5-difluoropyridine and aromatic boronic acid derivatives are reported.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Hadjar Benmansour, Richard D. Chambers, Graham Sandford, Andrei S. Batsanov, Judith A.K. Howard,