| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1315615 | Journal of Fluorine Chemistry | 2007 | 7 Pages |
Abstract
A new approach for the synthesis of fluorinated 1H-quinazolin-4-ones and 4-substituted quinazolines has been developed. 6-Fluoro-1H-quinazolin-4-ones were obtained by intramolecular cyclization of fluorine-containing S-ethyl N-benzoylisothioureas. Nucleophilic substitution reactions at positions 2 and 7, as well as alkylation at 1-position of quinazolinones were investigated. In addition, the synthesis of fluorine-containing 4-aminoquinazolines was carried out.
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Anastacia A. Layeva, Emilia V. Nosova, Galina N. Lipunova, Tatyana V. Trashakhova, Valerii N. Charushin,