Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1315666 | Journal of Fluorine Chemistry | 2006 | 4 Pages |
Abstract
A novel catalytic approach related to the enantioselective fluorination reaction using N-fluoroammonium salts of cinchona alkaloids which produces non-racemic α-fluoroketones is described. Acyl enol ethers of ketones 1 are enantioselectively fluorinated with Selectfluor® in the presence of a catalytic amount of cinchona alkaloid and 1.2 equivalents of sodium acetate at room temperature for 1–3 days to furnish α-fluoroketones 2 in good yields and moderate enantioselectivity (up to 54% ee).
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Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Takeo Fukuzumi, Norio Shibata, Masayoshi Sugiura, Shuichi Nakamura, Takeshi Toru,