Nanoflow microreactor for dramatic increase not only in reactivity but also in selectivity: Baeyer–Villiger oxidation by aqueous hydrogen peroxide using lowest concentration of a fluorous lanthanide catalyst

Not only the reaction rate but also the regioselectivity in the scandium bis(perfluorooctanesulfonyl)amide-catalyzed Baeyer–Villiger reaction is remarkably increased by the development of the fluorous nanoflow microreactor system continuously controlled by the nanofeeder DiNaS (Direct Nanoflow System) even in the lowest concentration of the catalyst (≪0.1 mol%). The Baeyer–Villiger reaction completes within few seconds as a contact time in the nanoflow microreactor to give the lactone products with high regioselectivity without hydrolysis.

Graphical abstractThe scandium bis(perfluorooctanesulfonyl)amide-catalyzed Baeyer–Villiger reaction is significantly increased in the regioselectivity as well as the reaction rate by the development of the fluorous nanoflow system. Figure optionsDownload full-size imageDownload as PowerPoint slide