Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1315687 | Journal of Fluorine Chemistry | 2006 | 4 Pages |
Abstract
The Perkin reaction of the activated aromatic ketones (2,2,2-trifluoroacetophenone and its 4′-phenyl-derivative) with various condensing agents (acetic anhydride, propionic anhydride, phenylacetic acid/acetic anhydride) gives the title compounds in good or moderate yields, and high E-stereoselectivity. For some derivatives an appreciable amount of the Z isomer was also formed. Several of the resulting butenoic acids and their methyl esters are synthesised and characterised for the first time.
Graphical abstractStereoisomeric CF3-substituted cinnamic acid derivatives have been prepared via the Perkin reaction using activated aromatic ketones. Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Szabolcs Cserényi, Károly Felföldi, Peter Forgo, István Pálinkó,