Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1315698 | Journal of Fluorine Chemistry | 2006 | 4 Pages |
Ring-opening fluorination reactions of epoxides using tetrabutylammonium bifluoride (TBABF)-KHF2, or Et3N-3HF under microwave irradiation were applied for the introduction of a fluorine atom into the carbohydrate molecules. When TBABF-KHF2 was used as the fluorination reagent, a fluorine atom was introduced regioselectively and various functional groups can tolerate the conditions. When Et3N-3HF was used under microwave irradiation, the reaction time could be remarkably shortened compared with the conventional oil-bath heating.
Graphical abstractRing-opening fluorination reactions of epoxides using tetrabutylammonium bifluoride (TBABF)-KHF2, or Et3N-3HF under microwave irradiation were applied for the introduction of a fluorine atom into the carbohydrate molecules. Figure optionsDownload full-size imageDownload as PowerPoint slide