Article ID Journal Published Year Pages File Type
1315710 Journal of Fluorine Chemistry 2006 4 Pages PDF
Abstract

A simple, convenient and effective method to synthesize 1,1,1,7,7,7-hexafluoroheptane-2,4,6-trione, the simplest fluorinated 1,3,5-triketone, on a preparative scale was developed. The title compound was obtained by a Claisen-type double condensation of acetone with trifluoroacetic acid ethyl ester and isolated as a solid monohydrate from the reaction mixture. Subsequent dehydration proceeds smoothly to produce the desired compound as an individual substance. Its peculiar tautomeric (keto–enol, ring–chain) features in various solvents are discussed.

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Related Topics
Physical Sciences and Engineering Chemistry Inorganic Chemistry
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