Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1315728 | Journal of Fluorine Chemistry | 2006 | 9 Pages |
Abstract
A series of fluorinated N-phenyl and N-benzyl-2-azaspiro[4.4]nonane- and [4.5]decane-1.3-dione derivatives, with F and CF3 substituents at the aromatic ring were synthesized, in order to determined the impact of such substitution on anticonvulsant activity. The incorporation of F and CF3 substituents enhanced the anticonvulsant efficacy.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Jolanta Obniska, Krzysztof Kaminski, Agnieszka Zagorska, Agnieszka Dzierzawska-Majewska, Janina Karolak-Wojciechowska,