| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1315824 | Journal of Inorganic Biochemistry | 2016 | 6 Pages |
•A manganese complex (Mn1)/water system as a dioxygen generator•Electrochemical properties of Mn1 and its loaded graphene oxide (Mn1@GO) were reported.•Mn1@GO can react with H2O2 resulting active anticancer species.•Mn1@GO was used as materials for hypoxic cancer phototherapy.•The mechanism of LED light enhanced anticancer activity was discussed.
Cancer cells are more susceptible to H2O2 induced cell death than normal cells. H2O2-activatable and O2-evolving nanoparticles could be used as photodynamic therapy agents in hypoxic environments. In this report, a photo-active Mn(II) complex of boradiazaindacene derivatives (Mn1) was used as a dioxygen generator under irradiation with LED light in water. Moreover, the in vitro biological evaluation for Mn1 and its loaded graphene oxide (herein called Mn1@GO) on HepG-2 cells in normal and hypoxic conditions has been performed. In particular, Mn1@GO can react with H2O2 resulting active anticancer species, which show high inhibition on both HepG-2 cells and CoCl2-treated HepG-2 cells (hypoxic cancer cells). The mechanism of LED light enhanced anticancer activity for Mn1@GO on HepG-2 cells was discussed. Our results show that Mn(II) complexes of boradiazaindacene (BODIPY) derivatives loaded GO can be both LED light and H2O2-activated anticancer agents in hypoxic environments.
Graphical abstractPhotoactive Mn(II) complex loaded GO (Mn1@GO) shows both LED light and H2O2-activated enhanced inhibition on the proliferation of HepG-2 cells in hypoxic conditions.Figure optionsDownload full-size imageDownload as PowerPoint slide
