| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1315906 | Journal of Inorganic Biochemistry | 2013 | 9 Pages |
Abstract
⺠Two models of HIV integrase inhibitors Elvitegravir and Raltegravir are synthesized. ⺠The two models are HIV integrase strand transfer inhibitors, as their progenitors. ⺠Ru(arene) complexes with the two model ligands are synthesized and characterized. ⺠The X-ray diffraction structures of one ligand and of two Ru complexes are discussed. ⺠Complexes are active at micromolar level in anti-HIV-1 integrase enzymatic assays.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Mauro Carcelli, Alessia Bacchi, Paolo Pelagatti, Gabriele Rispoli, Dominga Rogolino, Tino W. Sanchez, Mario Sechi, Nouri Neamati,