Synthesis, characterization and biological properties of cobalt(II) complexes of 1,10-phenanthroline and maltol

The synthesis and characterization of two cobalt(II) complexes, Co(phen)(ma)Cl 1 and Co(ma)2(phen) 2, (phen = 1,10-phenanthroline, ma− = maltolate or 2-methyl-4-oxo-4H-pyran-3-olate) are reported herein. The complexes have been characterized by FTIR, CHN analysis, fluorescence spectroscopy, UV–visible spectroscopy, conductivity measurement and X-ray crystallography. The number of chelated maltolate ligands seems to influence their DNA recognition, topoisomerase I inhibition and antiproliferative properties.

Graphical AbstractTwo cobalt(II) complexes of 1,10-phenanthroline and maltol have been synthesized and characterized. Their interaction with duplex and G-4 DNA, inhibition of Topoisomerase I and antiproliferative property against MDA-MB-231, MCF7 and MCF10A are reported herein.Figure optionsDownload full-size imageDownload as PowerPoint slide