| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1316034 | Journal of Inorganic Biochemistry | 2011 | 7 Pages |
We report here a thorough physico-chemical study of the coordination properties of clioquinol, an oxine-type active neurological drug in Alzheimer's disease, toward biologically relevant divalent metal ions (Cu, Zn, Ni, Co and Mn). Using a fruitful combination of electrospray mass spectrometry, absorption spectrophotometry and potentiometry, we have characterized the mono- and bis-chelated metal ion species. The determination of the stability constants showed a classical thermodynamic behavior along the studied series with the cupric complexes being by far the most stable species. Our data are discussed within the scope of Alzheimer's disease.
Graphical abstractThe ionic recognition properties of Clioquinol have been re-investigated. Independently of the nature of the metal ion (Mn(II), Co(II), Ni(II), Cu(II) and Zn(II)), mono- and bischelate species in solution were characterized.Figure optionsDownload full-size imageDownload as PowerPoint slide
