Antimicrobial activity of organotin(IV) complexes with the ligand benzil bis(benzoylhydrazone) and 4,4′-bipyridyl as coligand

Several methyltin(IV) and butyltin(IV) complexes with the ligand benzil bis(benzoylhydrazone) and 4,4′-bipyridyl as coligand were synthesised and characterized by elemental analysis and by IR, 1H, 13C and 119Sn NMR spectroscopies. Some of them were also analyzed using single crystal X-ray diffraction. The title compounds were evaluated for their in vitro antimicrobial properties. All buthyltin complexes showed significant inhibition of Gram positive bacteria, resulting Bacillus subtilis, Sarcina lutea and both methicillin-susceptible and methicillin-resistant Staphylococcus epidermidis the most sensitive strains. Furthermore, they were able to inhibit the growth of Gram negative bacteria, especially Proteus vulgaris, whereas no activity was exhibited against fungi. All methyltin complexes were devoid of antimicrobial properties.

Graphical AbstractSeveral organotin(IV) complexes with benzil bis(benzoylhydrazone) ligand and 4,4′-bipyridyl were synthesised and characterized and their antimicrobial properties evaluated. All buthyltin complexes showed significant inhibition of Gram positive bacteria. Furthermore, they were able to inhibit the growth of Gram negative bacteria. No antimicrobial activity was exhibited against fungi and by all methyltin complexes.Figure optionsDownload full-size imageDownload as PowerPoint slide