| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1316325 | Journal of Inorganic Biochemistry | 2011 | 6 Pages |
A series of bis(carboxylato)dichlorido(ethane-1,2-diamine)platinum(IV) compounds with IC50 values ranging between 142 μM and 18 nM was investigated with respect to their lipophilicity (by the shake flask method as well as microemulsion electrokinetic chromatography), reduction potential, as well as their cellular accumulation in cancer cells in vitro. In general, the antiproliferative properties of the complexes correlated with their lipophilicity as well as their accumulation, whereas differences in antiproliferative potency could not be explained by reduction potentials since they do not vary significantly within the investigated series of compounds. Only minor effects for complexes featuring polar end groups were detected.
Graphical AbstractNovel anticancer bis(carboxylato)platinum(IV) complexes were investigated with respect to their lipophilicity, reduction potential and cellular accumulation in correlation to their cytotoxicity. Principally, the antiproliferative properties correlated with the lipophilicity and cellular accumulation but not with the reduction potential.Figure optionsDownload full-size imageDownload as PowerPoint slide
