| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1316405 | Journal of Inorganic Biochemistry | 2007 | 10 Pages |
Abstract
The first examples of binuclear and mononuclear ortho-palladated complexes based on a functionalized 2-phenylquinoline ligand have been synthesized and fully characterized. Conjugating cyclopalladated fragments to curcumin family biologically active β-diketones gives in one single molecule two different functionalities. The structural variations based on the curcuminoid structure have been tested for their in vitro cytotoxic activity. The activity of complexes comprised of a cyclopalladated fragment conjugated to functionalized bioactive ligands, represents the potential of organometallic systems in generating new bifunctional biomaterials.
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Inorganic Chemistry
Authors
Daniela Pucci, Rossana Bloise, Anna Bellusci, Sergio Bernardini, Mauro Ghedini, Sante Pirillo, Alessandra Valentini, Alessandra Crispini,