| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1316406 | Journal of Inorganic Biochemistry | 2007 | 5 Pages |
Abstract
We report on the binding of cisplatin, carboplatin and oxaliplatin to double-stranded DNA in two different (phosphate and carbonate) buffers, using an electrochemical DNA-biosensor. The propensity of the electrophilic agent produced by hydrolysis to interact with DNA was measured as a function of the decrease of guanine oxidation signal of the metal–DNA adduct immobilized on a screen-printed electrode, by using square wave voltammetry. The results obtained confirm that carbonate reacts with platinum drugs to form activated carbonato complexes, which are able to react readily with DNA.
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Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Mauro Ravera, Graziana Bagni, Marco Mascini, James C. Dabrowiak, Domenico Osella,