Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1316567 | Journal of Inorganic Biochemistry | 2015 | 6 Pages |
•Four new ligands and their palladium(II) complexes were synthesized.•Characterized by microanalysis, infrared, 1H and 13C NMR spectroscopy•Cytotoxicity for ligands and complexes is investigated.
Four new ligands and their palladium(II) complexes of general formula R2-S,S-eddtyr (L1–L4) and [PdCl2(R2-S,S-eddtyr)] (C1–C4) (R = ethyl, n-propyl, n-butyl and n-pentyl; S,S-eddtyr·2HCl = ethylenediamine-N,N′-di-(2,2′-di(4-hydroxy-benzyl))-acetic acid dihydrochloride have been synthesized and characterized by microanalysis, infrared, 1H and 13C NMR spectroscopy. Cytotoxicity for ligands and complexes on two different cell lines (human breast cancer, MDA-MB-231 and human lung cancer, A549 cell lines) and human chronic lymphocytic leukemia cells (CLL) was investigated using MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) assay.
Graphical abstractThe complexes have been obtained by reaction of potassium-tetrachloridopalladate(II) with corresponding esters of ethylenediamine-N,N′-di-(2,2′-di(4-hydroxy-benzyl))-acetate dihydrochloride dihydrate. We investigated in vitro antitumor activity of these complexes and their ligands on two cell lines (human breast cancer, MDA-MB-231 and human lung cancer, A549 cell lines) and human chronic lymphocytic leukemia cells (CLL).Figure optionsDownload full-size imageDownload as PowerPoint slide