Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1316580 | Journal of Inorganic Biochemistry | 2008 | 10 Pages |
Abstract
A DNA-intercalating Ru(II) polypyridyl complex [Ru(bpy)2(appo)]2+ (bpy = 2,2′-bipyridine, appo = 11-aminopteridino[6,7-f][1,10]phenanthrolin-13(12H)-one) has been synthesized and characterized by elemental analysis, electrospray mass spectra, 1H NMR, UV/Vis spectrum, fluorescent spectrum and electrochemistry. The DNA-binding, photocleavage, and topoisomerase inhibition of the complex was studied. Interestingly, the complex binds to DNA via an intercalative mode with preference for GC sequences and cleaves the pBR322 DNA upon irradiation. In addition, the complex shows high inhibition activity against topoisomerase II by interfere the DNA religation.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Feng Gao, Hui Chao, Feng Zhou, Xin Chen, Yuan-Fang Wei, Liang-Nian Ji,