Article ID Journal Published Year Pages File Type
1316582 Journal of Inorganic Biochemistry 2008 11 Pages PDF
Abstract

The reactions of arene–metal complexes (arene = p-cymene, benzene or pentamethylcyclopentadienyl, metal = Ru, Rh or Os), including 1,3,5-triaza-7-phosphatricyclo-[3.3.1.1]decanephosphine (pta) and chloro co-ligands, with 9-methylguanine, adenine, and a series of nucleosides were studied in water to ascertain the binding modes. The products were characterized by NMR spectroscopy and electrospray ionization mass spectrometry (ESI-MS). Tandem mass spectrometry was found to provide excellent information on preferential binding sites. In general, the N7 position on guanine (the most basic site) was found to be the preferred donor atom for coordination to the metal complexes. The X-ray structures of the precursor complexes, [(η5-C10H15)RhCl(pta-Me)2]Cl2, [(η6-C10H14)OsCl(pta)2]Cl, and [(η6-C6H6)OsCl2(CH3CN)], are also reported.

Related Topics
Physical Sciences and Engineering Chemistry Inorganic Chemistry
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