Anti-tumor activities of Au(I) complexed with bisphosphines in HL-60 cells

We found that Au(I) complexed with 2,3-bis(tert-butyl(methyl)phosphino) quinoxaline (10) was a potent anti-tumor agent (half-maximal growth inhibitory concentration, GI50 = 0.87 μM) with broad anti-tumor activity. In particular, the activity of complex 10 was high in tumor cell lines derived from the colon and ovary. Treatment with complex 10 resulted in the apoptosis of HL-60 cells. The ligand for the preparation of complex 10 is commercially available implying that complex 10 might be a good drug candidate for cancer therapy.

Graphical abstractA Au(I) complexed with 2,3-bis(tert-butyl(methyl)phosphino) quinoxaline showed broad anti-tumor activity, and induced apoptosis in HL-60 cells.Figure optionsDownload full-size imageDownload as PowerPoint slide