Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1316752 | Journal of Inorganic Biochemistry | 2006 | 11 Pages |
Abstract
A flavonol iron(III) complex, [Fe(flavonolato)2Cl(MeOH)], has been prepared. The compound has been characterized by X-ray crystallography, spectroscopy, magnetism and electronic paramagnetic resonance (EPR) at X- and Q-band. The geometrical environment around the metal is best described as rhombic distorted octahedral. This distortion has also been inferred from the magnetic measurements and from the EPR spectra at different temperatures, E/D(rhombicity parameter) ≈ 0.06. The DNA cleavage activity of the iron(III) complex with and without ascorbate/hydrogen peroxide is reported. Mechanisms of the oxidative cleavage have been proposed when DNA strand scission is performed both with and without ascorbate/hydrogen peroxide activation.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Fátima Ben Allal El Amrani, Lourdes Perelló, Jose A. Real, Marta González-Alvarez, Gloria Alzuet, Joaquín Borrás, Santiago García-Granda, José Montejo-Bernardo,