| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1316772 | Journal of Inorganic Biochemistry | 2010 | 9 Pages |
Abstract
An amphiphilic porphyrin appended with a Ru(II)–polypyridyl complex (Ru–P) showing a moderate two-photon absorption cross-section (178.0 ± 26.8 GM), high singlet oxygen quantum yield and rapid cellular uptake was synthesized. In vitro study using human nasopharyngeal carcinoma cells showed that Ru–P exhibited a strong two-photon induced fluorescence upon uptake, lysosomal localization and potent two-photon induced cytotoxicity. These results show that Ru–P, which was designed to enhance its cellular uptake, can potentially be used as an efficacious bifunctional two-photon tumor-imaging and photodynamic therapeutic agent despite its moderate two-photon absorption cross-section.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Chun-Ting Poon, Pui-Shan Chan, Cornelia Man, Feng-Lei Jiang, Ricky Ngok Shun Wong, Nai-Ki Mak, Daniel W.J. Kwong, Sai-Wah Tsao, Wai-Kwok Wong,