Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1316795 | Journal of Inorganic Biochemistry | 2006 | 8 Pages |
Abstract
From the reaction of Super Hydride (LiBEt3H) with 6-(furyl)fulvene (1a), 6-(thiophenyl)fulvene (1b) or 6-(N-methyl-pyrrole)fulvene (1c) the corresponding lithium cyclopentadienide intermediates (2a-c) were obtained. These intermediates were reacted with titanium tetrachloride and bis-[(furyl-2-cyclopentadienylmethane)] titanium(IV) dichloride (3a) and bis-[(thiophenyl-2-cyclopentadienylmethane)] titanium(IV) dichloride (3b) and bis-[(N-methylpyrrole-2-cyclopentadienylmethane)] titanium(IV) dichloride (3c) were obtained and subsequently characterised by X-ray crystallography. When titanocenes 3a-c were tested against pig kidney (LLC-PK) cells inhibitory concentrations (IC50) of 1.6Â ÃÂ 10â4Â M, 1.5Â ÃÂ 10â4Â M and 9.1Â ÃÂ 10â4Â M, respectively, were observed. These values represent improved cytotoxicity against LLC-PK, when compared to their corresponding ansa substituted analogues and also in comparison to unsubstituted titanocene dichloride.
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Authors
Nigel Sweeney, William M. Gallagher, Helge Müller-Bunz, Clara Pampillón, Katja Strohfeldt, Matthias Tacke,