Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1316914 | Journal of Inorganic Biochemistry | 2005 | 7 Pages |
Abstract
To efficiently access asymmetric cis platinum (II) complexes for biological evaluation, a new solid-phase synthesis was designed. This synthesis was used for the preparation of a small library of platinum compounds. Several compounds from this library revealed promising activity during a cytotoxicity screen. Two active compounds were, therefore, synthesised on a larger scale and tested more extensively against a larger panel of cell-lines, confirming their high potential as antitumour compounds. The work presented illustrates how a combination of a new methodology and established techniques can speed up the search for platinum complexes with improved cytotoxic profiles compared to cisplatin.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Steven van Zutphen, Elizabeth A. Stone, Sabine van Rijt, Marc S. Robillard, Gijs A. van der Marel, Herman S. Overkleeft, Hans den Dulk, Jaap Brouwer, Jan Reedijk,