| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1316971 | Journal of Inorganic Biochemistry | 2016 | 9 Pages |
•Two water soluble heterometallic potassium–dioxidovanadium polymers are reported.•Both are characterized by single crystal X-ray diffraction analysis.•Their antiproliferative activities towards adenocarcinoma cell lines are examined.•One of them exhibits a high cytotoxic activity against colorectal carcinoma cells.
Two water soluble heterometallic potassium–dioxidovanadium polymers, [KVO2(L1)]n (1) and [KVO2(L2)(H2O)]n (2) [H2L1 = (2,3-dihydroxybenzylidene)-2-hydroxybenzohydrazide and H2L2 = (2,3-dihydroxybenzylidene)benzohydrazide], have been synthesized and characterized by IR, NMR, elemental analysis and single crystal X-ray diffraction. The antiproliferative potentials of 1 and 2 were examined towards human colorectal carcinoma (HCT116), and lung (A549) and breast (MCF7) adenocarcinoma cell lines. 1 exhibits a high cytotoxic activity against colorectal carcinoma cells (HCT116), with IC50 lower than those for cisplatin.
Graphical AbstractThe antiproliferative potentials of two water soluble heterometallic potassium–dioxidovanadium polymers [KVO2(L1)]n (1) and [KVO2(L2)(H2O)]n (2) were examined towards human colorectal carcinoma (HCT116), and lung (A549) and breast (MCF7) adenocarcinoma cell lines. 1 exhibits a high cytotoxic activity against colorectal carcinoma cells (HCT116).Figure optionsDownload full-size imageDownload as PowerPoint slide
