| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1317029 | Journal of Inorganic Biochemistry | 2015 | 9 Pages |
Abstract
Modulation of brain metal dyshomeostasis in neurodegenerative patients is crucial and so a set of cysteinyl-tacrine hybrid derivatives with anti-neurodegenerative properties was reevaluated for their possible extra-role as modulators of copper concentration and involvement on Aβ aggregation. These moderate Cu(II) chelators proved to improve inhibition of Aβ aggregation in the presence of copper.
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Catarina Quintanova, Rangappa S. Keri, SÃlvia Chaves, M. Amélia Santos,