| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1317676 | Journal of Inorganic Biochemistry | 2013 | 5 Pages |
A copper(II) complex with the non-steroidal anti-inflammatory drug (NSAID) diclofenac has been for the first time synthesized and characterized without any co-organic ligand. Its biological activity against four human cell lines underlined a higher activity of the monomeric complex than the parent molecule in the case of tumoral cell lines. A ternary Cu-diclofenac-albumin complex was suspected to be the reactive species in biological medium.
Graphical abstractA copper(II) complex with the non-steroidal anti-inflammatory drug (NSAID) diclofenac has been for the first time synthesized and characterized without any co-organic ligand. Its biological activity against four human cell lines underlined a higher activity of the monomeric complex than the parent molecule in the case of tumoral cell lines.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Novel copper(II) complex containing the non-steroidal anti-inflammatory drug diclofenac was synthesized and characterized. ► The complex was obtained as a mononuclear species without co-organic ligand. ► The monomeric complex showed a significant biological activity against human cell lines. ► The complex underlined a higher activity than the parent molecule in the case of tumoral cell lines.
