| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1317853 | Journal of Inorganic Biochemistry | 2012 | 8 Pages |
Controlled hydrolysis of donor-substituted titanium-salan complexes led to the formation of well-defined dinuclear complexes. Structure determination by means of X-ray and NMR-studies revealed the presence of a single μ-oxo bridge and one labile alkoxide ligand per titanium center. Concomitant cytotoxicity assays of the isolated dinuclear complexes showed cytotoxicities in the low micro-molar region, surpassing in this respect even their monomeric ancestors, thus making them possible highly active metabolites of titanium-salan anti-cancer drugs.
Graphical abstractControlled hydrolysis of donor-substituted titanium (IV) salan complexes led to the formation of well-defined dinuclear complexes with cytotoxicities in the low micro-molar region.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Donor substituted Ti(IV)salan complexes are cytotoxic in human cancer cell lines. ► Structurally characterized dinuclear complexes form upon fast hydrolysis. ►μ2-oxo bridged dinuclear complexes show enhanced cytotoxicity. ► First identified cytotoxic intermediates from Ti(IV)salan hydrolysis. ► Partial hydrolysis acts as activating mechanism.
