Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1317935 | Journal of Inorganic Biochemistry | 2010 | 10 Pages |
Two new ligand-containing histidine based on N,N′,N″-tris(N-benzyl-l-histidinyl)tri(2-aminoethyl)amine, L1, namely N,N′,N″-tris[(1S)-2-methoxy-2-oxy-1-(1-benzylimidazol-4-ylmethyl)]nitrilotriacetamide L2 and N,N′,N″-tris{N-benzyl-N-[N-benzyl-N-(N-benzyl-l-histidinyl)-l-histidinyl]-l-histidinyl}tri(2-aminoethyl)amine L3 were prepared. Zinc(II) binding studies by these ligand systems were analyzed by means of potentiometric and 1H NMR titrations in aqueous methanol (33 % v/v). Subsequently their zinc(II) complexes [L1Zn(H2O)](ClO4)2·HClO4 (1), [L2Zn(OH2)](ClO4)2·H2O (2), and ([L3Zn3(H2O)3](ClO4)6·3HClO4·5H2O (3), respectively were synthesized and characterized. The reactivity of the trinuclear complex (3) toward the hydrolysis of the toxic organophosphate parathion was investigated and compared with that of the mononuclear reference complex (1). From the pH dependence of the apparent rate constants, and the deprotonation constant (pKa) of the coordinated water molecules in (1), the active species were confirmed to be {[HL1Zn(OH)]2+/[L1Zn(H2O)]2+} at pH 8.5. The trizinc complex (3) effects hydrolysis of parathion, with three times rate enhancement over the mononuclear (1), indicating that cooperative action of the three zinc centers is limited.
Graphical AbstractKinetic studies reveal that the trinuclear complex [H3L3Zn3(H2O)3]6+ (3) affects hydrolysis of parathion, with three times rate enhancement over the mononuclear reference [HL1Zn(H2O)]3+ (1), indicating that cooperative action of the three zinc centers is limited.Figure optionsDownload full-size imageDownload as PowerPoint slide