| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1317950 | Journal of Inorganic Biochemistry | 2010 | 5 Pages |
The reaction of thiosemicarbazones (TSCs) with [AuI(THT)Cl], THT = tetrahydrothiophene, has been investigated. The resulting gold(I) complexes have been characterized by a range of spectroscopic techniques: NMR spectroscopy, mass spectrometry, microanalysis and infrared spectroscopy. The in vitro antimalarial data for gold(I) TSC complexes suggests that coordination of gold(I) to TSCs enhanced their efficacy against the malaria parasite Plasmodium falciparum and their inhibition of the parasite cysteine protease falcipain-2.
Graphical abstractThe synthesis and characterization of gold(I) compounds of the type [Au(HLn)2]+.CI−, wher HLn = thiosemicarbazones, n = 1−7, are described. In vitro biological evaluation of these thiosemicarbazone revealed enhanced antiplasmodial activity and inhibition of the malarial cysteine protease falcipain−2 compared to the free ligands.Figure optionsDownload full-size imageDownload as PowerPoint slide
