Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1317970 | Journal of Inorganic Biochemistry | 2010 | 6 Pages |
Abstract
Copper(II) complexes of histamine modified 2â²-deoxyriboadenosine (N-[(9-β-D-2â²-deoxyribofuranosylpurin-6-yl)-carbamoyl]histamine) ligand were studied by potentiometric, UV-visible and EPR techniques. The imidazole residue of the ligand was described as the main binding site forming mono-, bis-(ligand) and dimer complexes, but the interactions between adenosine nitrogen N(1) and carbamoyl nitrogen atoms and the copper(II) ion also were detected. This is the first report evaluating the coordinating ability of such a modified adenosine ligand towards copper(II) ion. Our findings suggest that histamine modified 2â²-deoxyriboadenosine could chelate efficiently copper(II) ions if it were incorporated into DNAzyme sequence.
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Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Elżbieta Åodyga-ChruÅciÅska, Elżbieta Sochacka, Damian Smuga, Longin ChruÅciÅski, Giovanni Micera, Daniele Sanna, Monika Turek, Monika GÄ
siorkiewicz,