| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1318217 | Journal of Inorganic Biochemistry | 2016 | 6 Pages |
Abstract
The new cyclic tetrapeptide c(HGHK) was synthesised in the solid phase and its complexes with copper(II) were studied in aqueous solution at various pH values by means of potentiometric and spectroscopic methods (UV, EPR, CD). Six mononuclear coordination species were clearly identified within the pH range 3–11. Spectroscopic data strongly suggest sequential formation of N, 2N, 3N and 4N equatorial donor sets around the copper(II) centre from the lowest to the highest pH, involving both imidazole nitrogens and amide nitrogens. A detailed comparison with the copper(II) binding properties of HGHG and Ac-HGHG ligands is also reported.
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Inorganic Chemistry
Authors
Justyna Brasun, Chiara Gabbiani, Mauro Ginanneschi, Luigi Messori, Marco Orfei, Jolanta Swiatek-Kozlowska,