Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1321338 | Journal of Organometallic Chemistry | 2014 | 4 Pages |
•Base-mediated demetallation of N-1 and N-3 substituted Fischer tungsten–carbene uracil complexes were studied.•Reaction on N-1 substituted Fischer tungsten–carbene uracil complexes gave excellent yield only using a large excess of base.•A practical and efficient synthesis of pyrimidin-2-ones derivatives is described.
A practical and efficient synthesis of pyrimidin-2-one derivatives from Fischer carbene complex uracil-analogues through base-mediated elimination reactions is described. The scope of the protocol has been explored with the preparation of a variety of pyrimidin-2-one derivatives by base mediated demetallation of N-1 and N-3 substituted uracil Fischer carbenes.
Graphical abstractFischer carbene complex uracil analogues were used for the synthesis of pyrimidin-2-ones. A practical and efficient methodology was optimized and applied to the preparation of a variety of pyrimidin-2-one derivatives.Figure optionsDownload full-size imageDownload as PowerPoint slide