Article ID Journal Published Year Pages File Type
1321338 Journal of Organometallic Chemistry 2014 4 Pages PDF
Abstract

•Base-mediated demetallation of N-1 and N-3 substituted Fischer tungsten–carbene uracil complexes were studied.•Reaction on N-1 substituted Fischer tungsten–carbene uracil complexes gave excellent yield only using a large excess of base.•A practical and efficient synthesis of pyrimidin-2-ones derivatives is described.

A practical and efficient synthesis of pyrimidin-2-one derivatives from Fischer carbene complex uracil-analogues through base-mediated elimination reactions is described. The scope of the protocol has been explored with the preparation of a variety of pyrimidin-2-one derivatives by base mediated demetallation of N-1 and N-3 substituted uracil Fischer carbenes.

Graphical abstractFischer carbene complex uracil analogues were used for the synthesis of pyrimidin-2-ones. A practical and efficient methodology was optimized and applied to the preparation of a variety of pyrimidin-2-one derivatives.Figure optionsDownload full-size imageDownload as PowerPoint slide

Related Topics
Physical Sciences and Engineering Chemistry Inorganic Chemistry
Authors
, , , , , ,