| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1321350 | Journal of Organometallic Chemistry | 2014 | 6 Pages |
•A series of novel ferrocene derivatives containing pyrazol-moiety were synthesized.•Isomeric compounds 4 and 5 were gave crystals suitable for X-ray structural analysis.•Compound 4d, 4j and 4k exhibited comparable in vitro antitumor activities.
A series of novel ferrocene derivatives containing pyrazolyl-moiety (4a–k, 5a–k) were synthesized. Their structures were characterized by 1H NMR, mass spectroscopy and element analysis. The crystals of isomeric compounds 4 and 5 were suitable for X-ray structural analysis. All the compounds were evaluated for their inhibitory activities against A549, HepG2 and MDA-MB-45 cell lines using the MTT method. Among them, compounds 4d, 4j and 4k exhibited comparable antitumor activities in vitro against A549 and MDA-MB-45 to the positive control 5-fluorouracil (5-FU).
Graphical abstractA series of novel ferrocene derivatives containing pyrazolyl-moiety were synthesized. Isomeric compounds 4 and 5 gave crystals suitable for X-ray structural analysis. All the compounds were evaluated the antitumor activity. Among them, compounds 4d, 4j and 4k exhibited comparable activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
